Today's organizations must be able to respond flexibly to change and develop the ability to constantly adapt business models according to new trends and opportunities. In this context, the concepts of strategic agility (SA) and business model innovation (BMI) are often cited by managers and consultants as approaches to help companies develop new competitive advantages. Based on a systematic literature review, this paper explores the relationship and synergies between these two concepts and then combines them into a holistic theoretical framework. Our framework provides 11 novel propositions that can be applied in future work to quantitatively test the relationship between SA and BMI. In addition, our framework sheds light on factors and concepts that have received little attention in describing the relationship between SA and BMI, such as organizational culture and IT-based capabilities. Another theoretical contribution of our work are new meta-capabilities of SA, which we apply for the first time to define SA based on approaches from the literature: strategic-innovative, resource-based, and internal-supporting capabilities. Our theoretical framework provides insights into elementary capabilities and conditions that must be present in order to actively apply both concepts in an organization.