Statistically, one in two individuals will get cancer during their lifetime. As the curability of cancer increases one focal question remains: How does this prevalent illness affect employees' careers after being cured? The complex societal challenge of health and wellbeing across the population is pertinent in Career Studies. This paper focuses on the career mobility of post-cancer employees, and seeks to add to this nascent research domain in Career Studies through an interdisciplinary systematic literature review. This is relevant and timely due to the increasing incidence and prevalence of cancer in the workplace, and its ubiquitous interdisciplinary importance. Supplementing extant knowledge pertaining to career transitions, our interdisciplinary systematic literature review of 23 studies provides further insights into the career mobility of cancer survivors. Following thematic synthesis, six analytical themes were identified. Integrating these themes with the liminal theoretical lens utilised in management studies, a theoretical process model of career mobility post-cancer was developed. The findings of this review contribute significantly to management and occupational health literature by adding further nuance to our understanding of how cancer survivors orient their careers post-treatment and what factors may impact their vocational decision-making process, informing organisational policies and practice.