We introduce Harmonized Organizational Principles for Ethics in Artificial Intelligence (HOPE AI), a novel conceptual framework designed to guide ethical AI integration in organizations. As AI reshapes various sectors, it presents societal challenges like job displacement, skill erosion, and changes in the nature and authenticity of work. Within an AI context specifically, we critically review traditional ethical philosophies (utilitarianism, deontology, relativism, virtue ethics), proposing new ethical considerations specific to AI’s organizational impact. HOPE AI addresses the ethical implications of AI’s organizational impact, focusing on a holistic approach to well-being, anticipatory governance, stakeholder inclusivity, and harmonization. We use a vignette to illustrate HOPE AI’s potential, highlighting challenges in role redefinition, loss of human touch, and ethical dilemmas. This new conceptual framework aims to ethically integrate AI advancements with human values, suggesting that its implementation can enhance stakeholder satisfaction and reduce ethical risks. Given cultural variability and rapid AI evolution, we suggest future HOPE AI research regarding its cross-cultural applicability, role in ethical leadership, integration into organizational ethics programs, and potential to offer a structured approach for ethically navigating AI in contemporary organizations.