If companies want to contribute to transforming a bioeconomy, their engagement in preserving biodiversity is key. Comprehensive measures for managing biodiversity are needed, encompassing setting goals, measuring impacts, and monitoring progress as well as embedding biodiversity in the organizational structure and culture. Measures are especially needed with regard to the main drivers of biodiversity loss, which are identified as (1) land and sea use change, (2) resource exploitation, (3) climate change, (4) pollution and (5) invasive non-native species. However, current biodiversity management frameworks fall short in guiding companies to embed different drivers of biodiversity loss or address comprehensive management systems which include organizational structures and culture. This paper addresses the gap in research by developing a processual biodiversity management framework that incorporates the drivers of biodiversity loss as well as comprehensive systems of management control, including the organizational setting. In doing so, it combines prominent intergovernmental frameworks on drivers of biodiversity loss with academic literature on biodiversity management and management control. Practical and theoretical implications of the new framework are presented and discussed. On the one hand, it may effectively contribute to the growth and upkeeping of the bioeconomy by guiding companies to protect and promote biodiversity. On the other hand, it makes crucial contributions to bioeconomy, biodiversity management and management control research.