This study delves into the intricate relationship between genetic predispositions, vocational interests, and career outcomes. Utilizing the Genome-Wide Association Study (GWAS) and Polygenic Scores (PGS), we investigated the heritability of vocational interests and their predictive power on occupational choices and income. The research introduces a novel 'gene-occupation fit' index, assessing the alignment between genetic predictions and actual occupations. Our findings, derived from the UK Biobank and Wisconsin Longitudinal Study samples, demonstrate a significant correlation between vocational interests and individual income. Specifically, the study reveals that gene-occupation fit notably predicts income, even after controlling for various occupational variables. Additionally, we explore the moderation effects of occupation classification on this relationship, finding significant positive interactions between gene-occupation fit and occupation types in determining income. These insights offer a nuanced understanding of the interplay between genetic factors, personal interests, and environmental influences in shaping career success.
