The current state of U.S. healthcare reflects the successes and challenges of satisfying the ever-changing healthcare needs of an increasingly complex society. Contemporary healthcare systems must continuously evolve to incorporate health policy updates, financial regulations for reimbursement and revenue recognition, prioritized patient experience and sustainability. There is no ‘one size fits all’ operations model in healthcare to implement these changes, but all stakeholders must make concerted efforts to maintain effective, efficient healthcare systems. This workshop discusses the key elements of systems effectiveness and efficiency and suggests innovative ways to move the healthcare sector forward.