This paper provides a scrutiny of the profound role that familial influences and genetic effects play in shaping human organizational behavior, particularly in leadership and career choices. Initially, we delve into the impacts of the family environment, encompassing socioeconomic, psychological/behavioral patterns, and genetic factors, on individual behavior, with a concentrated focus on their correlation with leadership and vocational selection. Despite these factors being instrumental in molding individual life trajectories, the paper highlights the oft-overlooked application of genetic research within the realm of social science. Subsequently, we provide an overview of the evolution of behavioral genetics and its application within social science, mapping the journey from twin and familial studies to candidate genes, and further to Genome-Wide Association Studies (GWAS) and Polygenic Risk Scores (PRS). Within this framework, we explore the concept of gene-environment interaction, taking into consideration the limitations and controversies associated with these studies. Ultimately, we discuss the future trajectory of gene-environment interaction research, specifically focusing on how to enhance our understanding and utilization of genetic information in studying social equity. By probing into the application of genetics in the study of organizational behavior and its integration with theoretical approaches, this study aims to shed new light on the understanding of human behavior and social equity.