Home care is typically characterized by a high need for coordinating the interdependent work of various healthcare professionals. However, there are often significant barriers for coordination among professionals, for instance, due to limited communication as a consequence of time constraints, spatially separated actors, and non-integrated information- and communication systems. Our study draws on the literature on patient involvement and coordination in healthcare to explore how patients and their relatives actively coordinate professional work in home care. We examine this question inductively based on multiple best-practice cases in the context of home care in Germany. Our findings reveal two distinct, yet equifinal, approaches that patients and their relatives apply when successfully coordinating home care: management by initial configuration and management by continuous synchronization. Both approaches comprise efforts to (1) supervise professionals’ work, (2) manage information and professionals’ information exchange, and (3) claim and exercise decision-making rights—yet these efforts differ considerably across the two approaches. We contribute to the understanding of patient involvement and coordination of healthcare in home care by unpacking the nature and dynamics of patients’ active self-involvement in the coordination of professional work.