Recent research has begun to reveal how and why hybrid entrepreneurs pursue non-monetary benefits, including important aspects of their work and identity such as autonomy. Despite these scholarly developments, there is a lack of consensus on how hybrid entrepreneurs experience these benefits.. This research addresses this open question by exploring when and how hybrid entrepreneurs experience autonomy in their dual work contexts. We do so by conducting a qualitative study of medical doctors in Ghana who simultaneously operate a business alongside their medical practice. This study advances a new model of entrepreneurial autonomy and contributes to emerging research on hybrid entrepreneurship from a qualitative lens.