Nurses are a critical part of the U.S. healthcare system. Yet, nurse turnover remains high. While many causes of nurse turnover exist, one understudied area is COVID-19 occupational stigma. Nurses may experience occupational stigma as they are in close proximity to sick patients, and the public may fear that they carry the disease. Nurse awareness of such stigma may cause them to experience occupational stigma consciousness. We examine the effects of nurse COVID-19 occupational stigma consciousness (OSC) on work burnout and job turnover intentions. We examine this through the lens of Conservation of Resources Theory with perceived supervisor support and supportive work climate as possible resource interventions. Results suggest that COVID-19 OSC contributes to work burnout, and work burnout fully mediates the relationship between COVID-19 OSC and job turnover intentions. Further, perceived supervisor support reduces both job turnover intentions and work burnout but neither moderate the negative impact of COVID-19 OSC on work burnout. This research contributes to our understanding of underlying causes of work burnout and job turnover intentions, the particularly harmful nature of COVID-19 OSC and highlights the need for additional interventions to reduce the negative impact of occupational stigma.